Array genotyping of transfusion-relevant blood cell antigens in 6946 ancestrally diverse study participants.

ABSTRACT:

Abstract

Blood transfusions save millions of lives worldwide each year, yet formation of antibodies against nonself antigens remains a significant problem, particularly in patients who receive frequent transfusions. We designed and tested the Universal Blood Donor Typing (UBDT_PC1) array for automated high-throughput simultaneous typing of human erythrocyte antigens (HEAs), platelet antigens (HPAs), leukocyte antigens (HLAs), and neutrophil antigens to support selection of blood products matched beyond ABO/Rh. Typing samples from 6946 study participants of European, African, Admixed American, South Asian, and East Asian ancestry at 2 different laboratories showed a genotype reproducibility of ≥99% for 17 244 variants, translating to 99.98%, 99.90%, and 99.93% concordance across 338

SUBMITTER: Gleadall NS 

PROVIDER: S-EPMC12824688 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature