CD99 promotes self-renewal in hematopoietic stem cells and leukemia stem cells by regulating protein synthesis.

ABSTRACT:

Abstract

Blood production is sustained by hematopoietic stem cells (HSCs), which are typically the only blood cells capable of long-term self-renewal. HSCs exhibit and depend on low levels of protein synthesis to self-renew. However, the mechanisms by which HSCs regulate protein synthesis to maintain their self-renewal capacity during proliferative stress and leukemogenesis remain unknown. Here we show CD99, a protein upregulated in leukemia stem cells (LSCs) in acute myeloid leukemia (AML), is required for the self-renewal of proliferating HSCs and LSCs. We found that loss of CD99 in HSCs and LSCs leads to increased protein synthesis, and that their self-renewal capacity can be restored by translation inhibition. These data demonstrate a functional role for CD99 in constraining pr

SUBMITTER: Ji Y 

PROVIDER: S-EPMC12824702 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature