Nuclear respiratory factor 1 promotes cell survival in multiple myeloma under proteasome inhibition therapy.

ABSTRACT:

Abstract

Multiple myeloma (MM) continues to be an incurable malignancy, even with recent therapeutic advancements. Although epigenetic dysregulation at cis-regulatory elements is known to drive disease progression, the complete molecular mechanisms underlying these alterations are poorly understood. Using Assay for Transposase-Accessible Chromatin with high-throughput sequencing analysis combined with the computational footprinting of CD138+ cells from 55 patients with MM, we depicted the dynamic changes in chromatin accessibility during disease progression and identified nuclear respiratory factor 1 (NRF1) as a master regulator of vital MM survival pathways. We demonstrated that NRF1 maintains proteasome homeostasis by orchestrating the ubiquitination pathway, which is essential f

SUBMITTER: Bruno T 

PROVIDER: S-EPMC12824706 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature