Biocompatibility of Nickel Ferrite Nanoparticles on Systemic and Testicular Cells.

ABSTRACT: Nickel ferrite nanoparticles (NPs) are chemically stable and have a surface suitable for functionalization, making them potential biotechnological tools in male reproduction. Herein, the nickel ferrite (FeNi) NPs were synthesized by the hydrothermal method and presented colloidal stability, low aggregation, high crystallinity, and superparamagnetic behavior at room temperature. At a dose of 500 μg/mL, FeNi NPs reduced the viability of systemic and male reproductive cells at all time points. We selected 100 μg/mL to further investigate its effects on testicular cells, as it was safe for VERO and AML-12 cells. For male reproductive cells, we observed that the selected FeNi NP dose significantly increased cell death by apoptosis and necrosis in Leydig cells, and by apoptosis in germ cells. We

SUBMITTER: Silva CCM 

PROVIDER: S-EPMC12824716 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature