Cyclization Reaction of α‑Hydroxyketones with Anthranilamides or 2‑Aminobenzenesulfonamides for the Synthesis of Quinazolinones and Benzothiadiazines.

ABSTRACT: We report in this research a novel and practical way for synthesizing quinazolin-4-(3H)-ones and the structural analogues (34 derivatives) and 1,2,4-(2H)-benzothiadiazine-1,1-dioxides (6 derivatives) using various α-hydroxyketones and anthranilamides or 2-aminobenzenesulfonamides as substrates with yields up to 96%. The method features cheap additives (only I₂ as a catalyst or I₂ and Fe³⁺ as catalysts and KMnO₄ as an oxidant), easy operation, and high atom utilization and provides a straightforward protocol for the preparation of these components of significant pharmacological potential.

SUBMITTER: Niu ZX 

PROVIDER: S-EPMC12824738 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature