Study on the Binding of Five Plant-Derived Secondary Metabolites to G‑Quadruplexes.

ABSTRACT: Chemical targeting of noncanonical secondary structures of DNA and RNA has emerged as a promising approach for therapeutic development. The most promising targets seem to be four-stranded structures in the G-rich regions of the genome, known as G-quadruplexes (G4s), which are associated with important regulatory regions including promoters. In this study, we tested and modeled the binding of five plant-derived secondary metabolites, known for their antiproliferative activity in vitro, to two G4s found in the human genome: the first at the c-Myc proto-oncogene and the second at the human telomere repeat region. Among the tested compounds, brucine exhibited the strongest interaction with both G4 sequences, while ellagic acid demonstrated binding efficacy comparable to that of brucine

SUBMITTER: Vrtalova L 

PROVIDER: S-EPMC12824740 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature