Design and Biological Evaluation of Palladium(II)-Phosphine-Benzimidazole Complexes as Dual Antioxidant and Antiangiogenic Agents.

ABSTRACT: The present study describes the design, synthesis, and characterization of two novel palladium-(II) complexes incorporating phosphine and benzimidazole ligands, followed by a comprehensive evaluation of their antioxidant and antiangiogenic properties. The complexes were fully characterized using spectroscopic and analytical methods. Antioxidant capacity was investigated through a multiassay approach, including ferrous ion-chelating activity, reducing power, and ABTS^•+ radical cation decolorization. Antiangiogenic activity was evaluated in vivo using the chick chorioallantoic membrane (CAM) assay. Palladium complex 1 exhibited the strongest ferrous ion-chelating ability (71.91% inhibition) and the highest ABTS^•+ scavenging activity (49.79%), while Palladium comp

SUBMITTER: Kiyan HT 

PROVIDER: S-EPMC12824747 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature