Psychological Therapy Quantity and Depressive Symptom Reduction in Psychedelic-Assisted Therapy: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Psychedelic-assisted therapy (PAT) is a novel intervention for depressive symptoms, typically delivered with additional psychological therapy sessions. Quantitative evidence on how this concomitant therapy contributes to treatment outcomes is limited, highlighting the need for a systematic synthesis.

Objective

To evaluate whether the quantity of psychological therapy is associated with symptom reduction in PAT for depressive symptoms.

Data sources

PubMed, PsycINFO, and Scopus databases were searched from inception to June 16, 2025.

Study selection

The analysis included controlled clinical trials involving adults with depressive symptoms who received PAT using classic serotonergic psychedelics (eg, psilocybin or lysergic acid diethylamide). Within the

SUBMITTER: Florineth GA 

PROVIDER: S-EPMC12824788 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature