Immune Escape-Related Gene NXT1 as a Potential Prognostic and Therapeutic Target in Hepatocellular Carcinoma.

ABSTRACT:

Background/aims

Hepatocellular carcinoma (HCC) constitutes approximately 85% of liver cancers. This study aimed to investigate the role of immune escape-related genes (IEGs) in HCC patients and analyze their relationship with prognosis and immunotherapy, thereby providing a reference for further clinical treatment.

Materials and methods

Datasets were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. Differential expression analysis was conducted to identify differentially expressed IEGs between normal and HCC tissues. Expression, survival, mutational, and immune profiles of a hub gene nuclear transport factor 2 like export factor 1 (NXT1) were evaluated. Validation of NXT1 expression in adjacent normal and HCC tissues was carried out using

SUBMITTER: Guo J 

PROVIDER: S-EPMC12824892 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature