Extent and predictors of guideline-directed medical therapy optimization during cardiac rehabilitation in patients with heart failure.

ABSTRACT:

Background

Cardiac rehabilitation (CR) may offer a structured framework for guideline-directed medical therapy (GDMT) optimization, but its real-world impact is uncertain. We aimed to quantify GDMT optimization and identify its clinical predictors during CR.

Methods

This retrospective single-centre study included patients hospitalized for acute HF with reduced (HFrEF) or mildly reduced (HFmrEF) ejection fraction who subsequently underwent first inpatient or ambulatory CR at Nancy University Hospital (2021-2024). Changes in GDMT optimization were evaluated using the HF prescription and the KCMO scores and expressed as adjusted standardized differences (ASD). Multivariable linear regression identified independent predictors of optimization.

Results

Among the 106 patient

SUBMITTER: Nicolas C 

PROVIDER: S-EPMC12824905 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature