Comparison of Nicotine and Selected Flavoring Contents Between Tobacco-Free and Tobacco-Containing Oral Pouches.

ABSTRACT:

Introduction

Flavored oral tobacco-free pouches (ONPs) are novel products that resemble traditional oral tobacco-containing pouches (OTPs) in design and route of administration. However, ONPs contain nicotine, various additives, and a filler material rather than tobacco leaves. Our study compares nicotine content, release, and form, along with selected flavoring content, between brands of ONPs and OTPs.

Methods

A convenience sample of flavored ONPs (n = 10 brands) and OTPs (n = 7 brands) was purchased between 2021 and 2023. Total nicotine content in the pouches, nicotine released over 1 hour, isomer ratio (R:S-nicotine), and 33 flavoring chemicals were measured using chromatography methods. Nicotine form (the proportion of nicotine in the protonated versus freebase forms) wa

SUBMITTER: Page MK 

PROVIDER: S-EPMC12824957 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature