Multiplatform Benchtop NMR Interlaboratory Study of Model Liquid Dosage Forms of Pharmaceutical Products.

ABSTRACT: Low-field NMR relaxometry uses water proton (¹H₂O) relaxation (wNMR) as a powerful and flexible tool to reveal deviations in critical quality attributes of liquid pharmaceuticals such as concentration or, in the case of proteins, aggregation. Measurements are fast and nondestructive, and many benchtop instruments can make measurements noninvasively, with an intact drug vial, prefilled syringe, or pen inserted directly into the probe. Because of the diversity of low-field instrument configurations and operating temperatures, the varying field strengths available, and the many possible protocols, pulse sequences, and parameters for conducting relaxation measurements, we sought to test the reproducibility of wNMR across platforms, and to identify the detail

SUBMITTER: Briggs KT 

PROVIDER: S-EPMC12824986 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature