Molecularly Imprinted Polymer-Based Electrogenerated Chemiluminescence Sensor for Sensitive and Selective Fentanyl Detection.

ABSTRACT: The escalating prevalence of fentanyl, a highly potent synthetic opioid responsible for rising overdose fatalities and public health crises, underscores the critical need for sensitive and selective detection methodologies. Herein, we report a molecularly imprinted polymer (MIP)-based electrogenerated chemiluminescence (ECL) sensor for ultrasensitive and selective quantification of fentanyl. The sensor was fabricated by electropolymerizing 4-aminobenzoic acid (4-ABA) on a glassy carbon electrode (GCE) in the presence of fentanyl as the template, followed by template elution to yield recognition nanocavities within the MIP film. ECL signal transduction was achieved through the anodic coreactant pathway, wherein fentanyl (as the coreactant) bound within the MIP cavities reacted with solution

SUBMITTER: Biswakarma A 

PROVIDER: S-EPMC12824990 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature