Effects of NGR1 on the Protective Efficacy and Functional Vision Profile of Retinal Photodamage.

ABSTRACT: Prolonged exposure to high-intensity light can harm macula vision, particularly affecting the function of Müller cells and cone photoreceptors. Panax notoginseng saponins (PNS) have valuable pharmacological effects on cerebrovascular, neurological, and microcirculatory health. Notoginsenoside R1 (NGR1), derived from PNS, shows potential for treating vascular or ischemia-reperfusion-related retinal issues; however, its impact on cone cells and the functional vision profile is not well understood. This study aimed to explore the effect and efficacy of NGR1 on retinal photodamage in vivo in mice. In a mouse model, high-intensity light causes significant photoreceptor damage, increases the production of pro-inflammatory factors, promotes Müller cell gliosis, and remarkably reduces the c

SUBMITTER: Chang CH 

PROVIDER: S-EPMC12825012 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature