Population pharmacokinetics of tofacitinib in patients with active ankylosing spondylitis.

ABSTRACT:

Objective

To characterize tofacitinib pharmacokinetics (PK) in patients with active ankylosing spondylitis (AS) and estimate the effects of covariates on variability of PK parameters.

Materials and methods

Pooled data from two studies in patients with AS who received tofacitinib were analyzed using nonlinear mixed-effects modeling. Tofacitinib PK was described by a one-compartment model parameterized in terms of apparent oral clearance (CL/F), apparent volume of distribution (V/F), and a first-order absorption rate constant (k_a). Covariates evaluated: baseline age, sex, race, creatinine clearance (BCCL), and C-reactive protein for CL/F; baseline age/body weight for V/F.

Results

Analysis included 279 patients. The point estimates for CL/F, V/F, and k_a</

SUBMITTER: Tsuchiwata S 

PROVIDER: S-EPMC12825014 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature