Single-dose HPV vaccination in the United States - a multi-modeling analysis.

ABSTRACT:

Background

Evidence supporting the non-inferior efficacy of single-dose human papillomavirus (HPV) vaccination has prompted reconsideration of existing multi-dose HPV vaccination schedules. We evaluated the long-term health impact of adopting single-dose HPV vaccination in the United States to inform policy deliberations.

Methods

We applied two validated individual-based simulation models of HPV transmission and cervical cancer to project the impact of switching from a two-dose to a single-dose HPV vaccination schedule in 2025 in the context of historical HPV vaccination uptake in the United States. Four scenarios were simulated: continuation of two-dose vaccination (or equivalent single-dose efficacy of 98%) and three alternative pessimistic single-dose strategies with lowe

SUBMITTER: Burger EA 

PROVIDER: S-EPMC12825051 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature