Hyperbaric oxygen protects against periodontal bone loss by modulating inflammation and bone remodeling via RANKL/OPG expression in ligature-induced periodontitis.

ABSTRACT: Periodontitis (PD) is a chronic inflammatory disease characterized by the accumulation of bacterial metabolites, sustained immune activation, and progressive loss of alveolar bone. Hyperbaric oxygen therapy (HBOT) has demonstrated anti-inflammatory and bone-reparative properties; however, its mechanistic effects in periodontitis remain underexplored. This study investigated whether HBOT mitigates periodontal bone loss and modulates bacterial, inflammatory, and osteoclastogenic pathways in a ligature-induced rat model. Sixty male Wistar rats underwent ligature placement for 28 days and were allocated into five groups (Sham, PD, PD+ natural recovery [RECOV], PD+early HBOT [EHBOT], PD+late HBOT [LHBOT]); HBOT was delivered as 100% oxygen at 2.0 ATA for 60 min/day. Gingival tissues were assess

SUBMITTER: Tu KW 

PROVIDER: S-EPMC12825118 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature