Roles of AFP, AFP-L3, DCP and GP73 in Diagnosis of Hepatocellular Carcinoma and Prediction of Recurrence in Patients.

ABSTRACT: Background: Alpha-fetoprotein (AFP), Des-gamma carboxy-prothrombin (DCP), lectin-bound AFP (AFP-L3) and Golgi protein-73 (GP73) have been used or proposed as surveillance tests for hepatocellular carcinoma (HCC). The aims of this study were to determine the performance of AFP, DCP, AFP-L3, GP73 and their combination in the diagnosis and prognosis of HCC. Methods: A total of 578 patients were enrolled, including 303 HCC patients, 104 patients with liver cirrhosis, 101 patients with chronic hepatitis and 70 healthy volunteers. The serum levels of AFP, DCP, AFP-L3 and GP73 were quantified before treatment, 7 days and 30 days after treatment. Results: AFP had the best area under the curve (AUC = 0.850), followed by DCP (0.775) and AFP-L3 (0.763), for the prediction of HCC,

SUBMITTER: Liao Y 

PROVIDER: S-EPMC12825132 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature