Acetaminophen is associated with improved survival in critically ill lung cancer patients: A propensity score-matched cohort study.

ABSTRACT: Background: Acetaminophen is widely used in intensive care units, yet its impact on mortality among critically ill patients with primary lung cancer remains unclear. Given the high disease burden and potential immunomodulatory effects of acetaminophen, robust evidence is needed to clarify its prognostic relevance in this population. Methods: We conducted a retrospective cohort study using the MIMIC-IV v2.2 database, including 1,127 critically ill patients with primary lung cancer. Baseline variables comprised demographics, comorbidities, illness severity scores (SOFA, APSIII, SAPSII, OASIS), and laboratory parameters. To minimize confounding, propensity score matching was applied. Results: A total of 1,127 critically ill patients with primary lung cancer were included,

SUBMITTER: Chen C 

PROVIDER: S-EPMC12825139 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature