Mapping the Hierarchical Environmental Transformations of Nanoscale UiO-66 Metal-organic Framework.

ABSTRACT: Metal-organic frameworks (MOFs) hold immense potential for applications from separations to catalysis, yet their long-term behavior across real-world environments remains unclear. Here we introduce a hierarchical exposure framework that tracks the structural and chemical transformations in the archetypal zirconium MOF UiO-66 across sequential compartments─atmospheric gases, air, aqueous media and a biological host─and resolves how prior exposures condition or prime subsequent transformations. Using synchrotron-based spectroscopy, we find that oxidative/reactive gases leave the Zr-carboxylate nodes essentially intact, whereas exposure to environmentally relevant aqueous media initiates partial shifts in local Zr coordination and introduces oxygen into the pores─with transformation extent go

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC12825163 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature