FOXP3-activated KCNMB2-AS1 promotes clear cell renal cell carcinoma through the miR-744-3p/CD1D axis.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) are key regulators in cancer progression. Among them, KCNMB2 antisense RNA 1 (KCNMB2-AS1) has been identified as an oncogenic lncRNA in several tumor types; however, its role in clear-cell renal cell carcinoma (ccRCC) remains largely unexplored. This study aimed to elucidate the expression profile, functional significance, and underlying molecular mechanisms of KCNMB2-AS1 in ccRCC.

Methods

The expression of KCNMB2-AS1 in ccRCC tissues and cell lines was analyzed using publicly available datasets, quantitative real-time PCR, and Western blotting. Functional assays including Cell Counting Kit-8, colony formation, wound healing, and Transwell migration/invasion tests along with in vivo xenograft experiments were performed to assess its b

SUBMITTER: Huang G 

PROVIDER: S-EPMC12825252 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature