Molecular epidemiological characteristics, antifungal resistance and pathogenicity of Candidozyma auris in Guangzhou, South China.

ABSTRACT: BACKGROUND : Candidozyma (candida) auris poses a global health threat with increasing incidence in China, yet the molecular epidemiology and virulence traits of this pathogen remain insufficiently characterized.

Methods

This study conducted a comprehensive analysis of 39 C. auris isolates from 37 patients in three hospitals in Guangzhou using whole genome sequencing (WGS), antifungal susceptibility testing, extracellular hydrolase detection, biofilm-forming capacity assessment, and a Galleria mellonella infection model. Single nucleotide polymorphism (SNP) analysis, phylogenetic analysis, and resistance gene analysis were performed based on the WGS data.

Results

Phylogenetic analysis identified two major clades: Clade I (74.4%) and Clade III (25.6%), with co-infection by both

SUBMITTER: Wan G 

PROVIDER: S-EPMC12825283 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature