Species-Specific Parent-Of-Origin Expression of Adam23 in the Mammalian Brain.

ABSTRACT: Genomic imprinting is a parent-of-origin-dependent epigenetic mechanism with established roles in placental development and fetal growth in mice, whereas its contribution to brain function and evolution remains incompletely understood. Here, we investigated parent-of-origin-biased gene expression in the ferret, a gyrencephalic mammal whose cortical architecture more closely resembles that of humans than mice. Guided by human imprinting datasets, we screened 65 candidate genes in the ferret brain and identified paternal allele-biased expression of Adam23, maternal bias of Atp10a, and biallelic expression of genes including Pxdc1, Wrb, and Ube3a. Adam23 showed paternal bias in the ferret cortex, most prominently in the occipital region, whereas it was biallelically expressed in mouse brain.

SUBMITTER: Meguro-Horike M 

PROVIDER: S-EPMC12825345 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature