Adsorption of Mixed Micelles of Polysorbate 80 and Oleic Acid to the Air-Water Interface.

ABSTRACT: The solubilization of long chain amphiphiles with limited solubility into mixed micelles composed of highly soluble surfactants plays a crucial role in modulating the stability and functionality of formulations in pharmaceutical and food systems. Subsequently, the mixed micelles adsorb from solution to the air-water surface, defining the transport mechanism of the insoluble amphiphiles to the interface. We use X-ray reflectivity to measure the composition and provide insight into the structure of these mixed monolayers, and, alongside interfacial tension measurements, we provide an understanding of how the bulk composition determines the surface composition and the dynamics of tension reduction. We use a model system consisting of an insoluble fatty acid, oleic acid (OA), and a soluble mic

SUBMITTER: Ayati NS 

PROVIDER: S-EPMC12825370 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature