Introduction of Temperature-Gradient Elution in Three-Dimensional Correlation Thermal Field-Flow Fractionation with Quintuple Detection for Monitoring Compositional Dynamics of Ultrahigh-Molar-Mass Poly(styrene-<i>co</i>-maleic anhydride).

ABSTRACT: Analogous to temperature-gradient interaction chromatography, temperature-gradient elution three-dimensional correlation thermal field-flow fractionation (TGE-3DCoTF3) coupled with quintuple-detection provides high-resolution analysis of ultrahigh-molar-mass poly(styrene-co-maleic anhydride) synthesized via biradical photoinitiation. TGE-3DCoTF3 resolves more than 3 orders of magnitude in molar-mass, cleanly separating residual monomers and oligomers from megadalton copolymers while preserving their integrity. Multidetector correlation yields molar-mass, three independent radii, intrinsic viscosity, diffusion coefficient, thermal diffusion coefficient (D_T) and UV-vis spectra. Differential UV-vis absorptivity distinguishes unreacted monomers from copolymers, enablin

SUBMITTER: Muza UL 

PROVIDER: S-EPMC12825381 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature