Surface-Attached Model Lipid Membranes Derived from Human Red Blood Cells.

ABSTRACT: Red blood cells (RBCs) are the most abundant human cell type, and interactions with the RBC membrane are at the heart of many processes relevant for human health, such as immune system modulation, as well as binding by foreign pathogens and pharmacological drugs. To better study such membrane interface interactions, it would be useful to employ surface-attached model lipid membranes derived from RBCs to enable surface-sensitive biophysical and biochemical measurements. Here, we present approaches to prepare two such types of RBC-derived model lipid membranes─tethered RBC liposomes and supported lipid bilayers (RBC-SLBs)─as well as characterization and validation data. Both model membranes are prepared from liposomes formed by extrusion from RBC ghosts. Tethered RBC liposomes are assembled

SUBMITTER: Mudakannavar SP 

PROVIDER: S-EPMC12825389 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature