Complement and Coagulation Cascades Pathway was Inactivated in HIV-Associated Colorectal Cancer: Results from a Proteomics Study.

ABSTRACT: Background: Colorectal cancer (CRC) remains a leading cause of global cancer-related morbidity and mortality. Human Immunodeficiency Virus (HIV)-1 infection worsens colorectal cancer (CRC) outcomes. Methods: To investigate mechanisms, we conducted Tandem Mass Tag proteomics on tumor (C) and adjacent normal tissues (A) from five HIV-positive (HIV+) and four HIV-negative (HIV-) CRC patients. Four comparisons were analyzed: HIV+C vs HIV+A (differentially expressed proteins, (DEPs)-1), HIV-C vs HIV-A (DEPs-2), HIV+A vs HIV-A (DEPs-3), HIV+C vs HIV-C (DEPs-4) (|fold change| ≥ 2, p < 0.05). The DEPs specifically affected by HIV (DEPs-5) underwent KEGG pathway enrichment analysis. The relative abundance of pathway-associated DEPs was compared with the data from CPTAC database. Key D

SUBMITTER: Lian S 

PROVIDER: S-EPMC12825422 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature