The roles of CD24-Sec14 like lipid binding 2 (SEC14L2) axis in the neoplastic progression of oral squamous cell carcinomas.

ABSTRACT:

Background/purpose

Immune stimulation or escape are critical factors determining the survival of malignancies, including oral squamous cell carcinoma (OSCC) and head and neck SCC (HNSCC). CD24 (CD24A in mice) is a glycoprotein anchored to cell membranes, modulating macrophages' immune responses, cell interaction, tumorigenesis, and stemness. However, its roles in the OSCC pathogenesis are still controversial. The modulation of CD24 on the oncogenicity and immunity of OSCC were investigated in this study.

Materials and methods

Knockdown approaches and the establishment of stable tet-off CD24 expression cell subclones were used in cell and mouse models for phenotypic and transcriptomic analysis. Bioinformatic assessments were performed to specify the clinicopathological implic

SUBMITTER: Chang SR 

PROVIDER: S-EPMC12825469 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature