Suppression of distal-less homeobox 3 increased alveolar bone mass in mouse tooth socket by targeting thrombospondin 1.

ABSTRACT:

Background/purpose

Alveolar ridge resorption after tooth extraction significantly impacts dental implantation and prosthodontic treatment outcomes. Sustaining alveolar bone mass remains a critical clinical challenge and a major focus of research. Notably, patients with tricho-dento-osseous (TDO) syndrome, characterized by distal-less homeobox 3(DLX3) loss-of function mutations, exhibit increased jaw bone density and demonstrate long-term preservation of alveolar bone mass post-tooth extraction. This study aimed to investigate the effects of DLX3 knockdown on bone remodeling following tooth extraction and to elucidate the underlying molecular mechanisms.

Materials and methods

we established a murine maxillary incisor extraction model to investigate alveolar bone

SUBMITTER: Diao C 

PROVIDER: S-EPMC12825486 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature