Natural history of S-adenosylmethionine-binding proteins.

ABSTRACT:

Background

S-adenosylmethionine is a source of diverse chemical groups used in biosynthesis and modification of virtually every class of biomolecules. The most notable reaction requiring S-adenosylmethionine, transfer of methyl group, is performed by a large class of enzymes, S-adenosylmethionine-dependent methyltransferases, which have been the focus of considerable structure-function studies. Evolutionary trajectories of these enzymes, and especially of other classes of S-adenosylmethionine-binding proteins, nevertheless, remain poorly understood. We addressed this issue by computational comparison of sequences and structures of various S-adenosylmethionine-binding proteins.

Results

Two widespread folds, Rossmann fold and TIM barrel, have been repeatedly used in evolution

SUBMITTER: Kozbial PZ 

PROVIDER: S-EPMC1282579 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature