Functional insights into the photoactive yellow protein family from homologs, multidomain proteins, and inferred <i>pyp</i> operons.

ABSTRACT: Photoactive Yellow Protein (PYP) is a model system for functional protein dynamics and a prototype of the PAS domain superfamily. It is a bacterial photoreceptor that triggers a range of responses in different bacteria: phototaxis, biosynthesis of photo-protective pigments, and light regulation of biofilm formation. An important gap in knowledge on PYP is the signal transduction chain that guides the initial signal from the photoreceptor to various biological responses. Here, we present an expanded set of 984 PYP homologs, providing information on sequence conservation and variation. We analyze this set of PYPs using two bioinformatics approaches to identify candidate proteins that are functionally related to PYP. First, we identified 153 multi-domain proteins containing PYP and analyzed t

SUBMITTER: Dohmen RL 

PROVIDER: S-EPMC12826048 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature