<i>Yersinia pestis</i> plasminogen activator protease is regulated by the PhoP/PhoQ two-component system.

ABSTRACT: Yersinia pestis is a gram-negative bacterium and the causative agent of plague. The Y. pestis virulence factor plasminogen activator protease (Pla) is an outer membrane aspartic protease that facilitates the dissemination of bacteria from the site of inoculation to deeper tissue during bubonic plague. During pneumonic plague, Pla acts as an adhesin, which contributes to the suppression of early innate immune responses in the lungs, and as a protease that aids in resisting bacterial killing by neutrophils. Two-component regulatory systems (TCSs) are involved in bacterial adaptation to environmental stressors such as changes in pH, changes in ion concentrations, and the presence of cationic antimicrobial peptides. TCSs consist of a membrane-bound sensor kinase that detects envi

SUBMITTER: Appell KT 

PROVIDER: S-EPMC12826059 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature