Causality between immune cells and HER2-breast cancer: A 2‑sample Mendelian randomization study.

ABSTRACT: This study represents the first investigation employing 2-sample Mendelian randomization (MR), multi-marker analysis of genomic annotation (MAGMA), Metascape, and the Kaplan-Meier (K-M) plotter database to elucidate the causal relationship between immune cells (ICs) and human epidermal growth factor receptor 2 negative breast cancer (HER2-BC). The findings provide genetic evidence supporting the association between ICs and HER2-BC risk. The 2-sample data for the Mendelian randomization study were sourced from public databases. In this study, ICs were selected as the exposure factor, and HER2-BC was taken as the outcome factor. MR analysis was conducted on the causal relationship between ICs and HER2-BC by using various regression models. Gene-based analysis was carried out through MAGMA, a

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12826194 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature