DNA methylation age acceleration mediates the relationship between systemic inflammation and cognitive impairment.

ABSTRACT:

Background

Chronic inflammation and DNA methylation are potential mechanisms in dementia etiology. The linkage between inflammation and DNA methylation age acceleration in shaping dementia risk remains understudied. We explored the association of inflammatory cytokines with cognitive impairment and whether DNA methylation age acceleration mediates this relationship.

Research design and methods

Using data from the 2016 Health and Retirement Study (n = 3,346, age >50), we estimate the associations between each inflammatory cytokine (interleukin-6 (IL-6), C-reactive protein (CRP), and insulin-like growth factor-1 (IGF-1)), and cognitive status, classified using the Langa-Weir method. We tested if DNA methylation age acceleration mediated the relationship between systemic

SUBMITTER: Higgins Tejera C 

PROVIDER: S-EPMC12826733 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature