Loss of Lipin1 Contributes to Multiple Pathological Processes in the Development of Heart Failure.

ABSTRACT:

Background

Lipin1 has dual functions acting as phosphatidic acid phosphatase required for lipid synthesis and as a transcriptional coactivator. Our previous research demonstrated that lipin1 is critical for maintaining sarcolemmal integrity in skeletal muscle. Given the importance of sarcolemmal stability for cardiac muscle viability and function, we investigated the role of lipin1 in the heart using a novel cardiac-specific lipin1 deficient (Myh6-lipin1^-/-) mouse model.

Methods

We characterized male Myh6-lipin1^-/- mice at 3 to 4 months of age to assess cardiac structure and function.

Results

Myh6-lipin1^-/- mice exhibited marked cardiac inflammation, fibrosis, increased expression of cell death

SUBMITTER: Kamau JK 

PROVIDER: S-EPMC12826883 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature