Differential Effects of Intravenous Versus Intracoronary Adenosine on Non-Culprit Lesion Assessment Following Acute Coronary Syndrome.

ABSTRACT:

Background

During acute coronary syndrome (ACS), the validity of initial non-culprit fractional flow reserve (FFR) measurements remains controversial because of microvascular dysfunction and potential diminished adenosine response. Because the hyperemic effects of adenosine have been predominantly studied in stable patients, and high-dose intracoronary administration may produce stronger hyperemia than intravenous delivery, we compared non-culprit FFR between the acute and stabilized phases of ACS using both administration routes.

Methods

Patients presenting with ACS underwent repeated physiological assessment of relevant non-culprit lesions using both intracoronary adenosine boluses (≥100 μg) and intravenous adenosine (140 μg/kg/min) during index hospitalization and at 12-w

SUBMITTER: Los J 

PROVIDER: S-EPMC12826888 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature