Extending Dual Antiplatelet Therapy Beyond 3 Months in Acute Ischemic Stroke Due to Large-Artery Atherosclerosis.

ABSTRACT:

Background

The optimal duration of dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel following acute ischemic stroke due to large-artery atherosclerosis remains uncertain.

Methods

We retrospectively analyzed data from a prospective, multicenter stroke registry (2011-2018) linked to a national health insurance claims database. Patients included had acute ischemic stroke attributable to large-artery atherosclerosis, initiated DAPT within 48 hours of admission and remained free of primary outcome events during the first 30 days. Temporal trends in DAPT usage were evaluated, and landmark analyses assessed the impact of DAPT continuation for up to 6 months after stroke on clinical outcomes. The primary outcome was a composite of recurrent stroke, myocardial infarctio

SUBMITTER: Lee M 

PROVIDER: S-EPMC12826892 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature