Urine Tubular Biomarkers Are Associated With Natriuresis in Patients With Acute Heart Failure.

ABSTRACT:

Background

Loop diuretics require functioning kidney tubules to increase the excretion of sodium into urine thereby relieving congestion in patients with acute heart failure (AHF). Whether biomarkers of kidney tubular health are associated with the natriuretic response of loop diuretics in AHF is unknown.

Methods

Spot urine sodium and 14 urine biomarkers of tubular health were measured after intravenous loop diuretic administration on the day of enrollment in 418 patients with AHF from AKINESIS (Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin [NGAL] Evaluation of Symptomatic Heart Failure Study). The association of each biomarker with urine sodium concentration was assessed with multivariable linear regression.

Results

The mean age was 71±12 years, 64%

SUBMITTER: Wettersten N 

PROVIDER: S-EPMC12826899 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature