Association of Subgingival Microbiota Composition With Risk, Severity, and Outcome of Cryptogenic Ischemic Stroke in Young Adults.

ABSTRACT:

Background

Oral and gut dysbiosis has been linked to stroke pathogenesis and its prognosis. However, the relationship between the subgingival microbiota and cryptogenic ischemic stroke (CIS) remains unclear. We compared the subgingival microbiota of patients with CIS and their age-and sex-matched stroke-free controls to identify the specific microbiota associated with CIS, stroke symptom severity, and clinical outcome.

Methods

This multicenter, case-control study was conducted between 2013 and 2019 as part of a screening protocol for the SECRETO (Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome) study (NCT01934725). Stroke severity was assessed using the National Institutes of Health Stroke Scale score. After thoro

SUBMITTER: Manzoor M 

PROVIDER: S-EPMC12826904 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature