Associations Between Plasma Omega-3 and Fish Oil Use With Risk of Atrial Fibrillation in the UK Biobank.

ABSTRACT:

Background

Meta-analyses of randomized trials with omega-3 products found an increased risk of atrial fibrillation (AF), and a recent study from the UK Biobank concluded that fish oil supplement (FOS) use was likewise associated with increased risk of AF. Conversely, a meta-analysis based on blood levels of omega-3 fatty acids found an inverse relationship with AF risk. Thus, the relationship between omega-3 fatty acids and risk of AF remains unclear.

Methods

We conducted a retrospective analysis of UK Biobank data to link both plasma omega-3 levels and reported FOS use with AF risk. Among participants without prevalent AF, a random sample of 261 108 had data on plasma omega-3 levels and 466 169 reported about FOS use. The primary outcome was incident AF during follow-up (me

SUBMITTER: O'Keefe E 

PROVIDER: S-EPMC12826911 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature