What Should a Clinical Cardiologist Know About Cardiogenetics?

ABSTRACT: Inherited cardiovascular diseases are becoming increasingly prominent in clinical practice, significantly impacting diagnosis, risk assessment, and family screening strategies. Progress in genetic testing has broadened access to cardiogenetic evaluations, while also presenting new challenges in interpreting variants and incorporating findings into clinical care. This narrative review explores 20 essential questions that clinical cardiologists may face when dealing with suspected or confirmed inherited cardiac conditions. Organized as a practical, question-driven guide, it outlines when to consider a genetic cause, how to choose and interpret genetic tests, and how to manage patients regardless of their genetic test results. The review emphasizes variant classification based on American Col

SUBMITTER: Faggiano A 

PROVIDER: S-EPMC12826912 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature