Extreme Heat Exposure Enhanced the Associations Between Prepregnancy Weight and the Hypertensive Disorders of Pregnancy and Endothelial Dysfunction.

ABSTRACT:

Background

Prepregnancy overweight or obesity may increase cardiovascular risk, but whether extreme heat intensifies its association with hypertensive disorders of pregnancy (HDPs) or endothelial dysfunction (ED) is unclear.

Methods

In this population-based cohort of 7820 pregnant women, prepregnancy body mass index and HDPs were obtained from hospital records. Ambient temperature data were sourced from the National Centers for Environmental Information. Plasma endothelial biomarkers (VCAM-1 [vascular cell adhesion molecule-1], ICAM-1 [intercellular adhesion molecule-1], E-selectin) were measured at 24 to 28 weeks' gestation, and latent profile analysis defined ED. Generalized linear and restricted cubic spline models assessed associations between prepregnancy overweight or

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12826915 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature