Changes in Expression Profiles of Caspase-8 and Mixed Lineage Kinase Domain-Like Protein/Receptor-Interacting Protein Kinase 3 Mediated by Inflammation in Cerebral Arteriovenous Malformations Associated With Clinical Condition on Admission.

ABSTRACT:

Background

Cerebral arteriovenous malformations (cAVMs) are complex vascular anomalies carrying a high risk of hemorrhage due to abnormal arteriovenous connections. Recent studies have highlighted the roles of inflammation and KRAS mutations in the pathogenesis of cAVM. Necroptosis is a programmed cell necrosis pathway mediated by RIPK3 (receptor-interacting protein kinase 3) and MLKL (mixed-lineage kinase domain-like protein). The pathway, which is inhibited by caspase-8, plays multifunctional roles in various diseases. However, the involvement of necroptosis and its relationship with caspase-8 in the pathogenesis of cAVM remain unclear.

Methods

We analyzed tissue samples from 23 patients with cAVM in comparison with normal brain tissues. Proteome profiling, immunohi

SUBMITTER: Shimada K 

PROVIDER: S-EPMC12826922 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature