Identification and Validation of Differentially Expressed mRNAs From Peripheral Leukocytes for Acute Stanford Type A Aortic Dissection.

ABSTRACT:

Background

Acute Stanford type A aortic dissection (ATAAD) is lethal and has a high mortality rate, but few useful biomarkers are available for its diagnosis. This study aimed to identify and validate differentially expressed mRNAs in ATAAD from peripheral leukocytes.

Methods

RNA sequencing was performed using peripheral blood leukocyte samples from 8 patients with ATAAD and 20 controls to screen differentially expressed mRNAs. A 2-stage case-control study consisting of 178 patients with ATAAD and 178 healthy controls was conducted to validate the 20 upregulated and 20 downregulated differentially expressed mRNAs. Then, a stage 3 case-control study consisting of 64 patients with ATAAD, 64 patients with acute myocardial infarction, and 64 controls was used for discriminative

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12826926 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature