Glucagon-Like Peptide-1 Receptor Agonists Versus Bariatric Surgery in Patients With Obesity and Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

To compare the effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) versus bariatric surgery on cardiovascular outcomes in patients with heart failure (HF) with preserved ejection fraction and obesity.

Methods

Using the TriNetX research network, we conducted a retrospective cohort study of adults (aged ≥18 years) with HF with preserved ejection fraction and obesity (body mass index >30 kg/m²) from 2017 to 2022. Patients were categorized into 2 cohorts: those receiving GLP-1 RAs (semaglutide or tirzepatide) and those who underwent bariatric surgery. Propensity score matching (1:1) was used to balance baseline characteristics. Primary outcomes included acute HF events and all-cause hospitalizations. Secondary outcomes included all-cause

SUBMITTER: Ibrahim R 

PROVIDER: S-EPMC12826936 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature