Ultrasound-Propelled ferroptosis catalytic amplification for Active-targeting sonodynamic anti-tumor therapy with Concurrent Photoacoustic/MRI visualization.

ABSTRACT: Sonodynamic therapy (SDT) faces significant challenges in treating aggressive malignancies due to inherent apoptotic resistance. To address this, we developed a multifunctional nanoliposome designed for mitochondrial targeting and synergistic induction of dual cell death pathways. Co-loaded with the sonosensitizer HMME and an iron-based Fenton catalyst, the nanoparticle exhibits glutathione-responsive disassembly and promotes robust reactive oxygen species generation under ultrasound irradiation. This leads to potent lipid peroxidation and ferroptosis, effectively bypassing conventional resistance mechanisms. The platform further integrates dual-modal magnetic resonance and photoacoustic imaging capabilities, enabling precise tumor delineation and real-time treatment monitoring. Constructe

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12827029 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature