Potential Effect of Belladonna in the Management of Convulsions in Zebrafish (<i>Danio rerio</i>) and In Silico Mechanistic Approach.

ABSTRACT:

Background

Convulsions (seizures) are common neurological conditions characterised by abnormal electrical activity in the brain. Various modern treatments are available for managing convulsions; however, due to the side effects of available treatments, alternative medicine is gaining attention. One of the most popular homoeopathic remedies is Belladonna, used for treating neurological symptoms such as seizures, but scientific evidence is not available.

Purpose

The present study was designed to evaluate its anticonvulsive effect in the zebrafish animal model.

Methodology

The effect of homoeopathic Belladonna on pentylenetetrazole (PTZ)-induced seizures in zebrafish (Danio rerio) was assessed in this study. The safe dose was identified through acute toxicity studies, wh

SUBMITTER: Sharma M 

PROVIDER: S-EPMC12827039 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature