Genetic contributions to Alzheimer's disease and frontotemporal dementia in admixed Latin American populations.

ABSTRACT: Latin America's diverse genetic landscape provides a unique opportunity to study Alzheimer's disease (AD) and frontotemporal dementia (FTD). The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat) recruited 2162 participants with AD, FTD, or healthy controls from six countries: Argentina, Brazil, Chile, Colombia, Mexico, and Peru. Participants underwent genomic sequencing, and population structure analyses were conducted using Principal Component Analysis and ADMIXTURE. The study revealed a predominant mix of American, African, and European ancestries, with an additional East Asian component in Brazil. Variant curation identified 17 pathogenic variants, a pathogenic C9orf72 expansion, and 44 variants of uncertain significance. Seventy families showed autos

SUBMITTER: Acosta-Uribe J 

PROVIDER: S-EPMC12827047 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature