Plasma vascular endothelial growth factor levels are a potential therapy-response biomarker for pancreatic cancer.

ABSTRACT:

Introduction

Cytokines have long been studied for their role in the pathophysiology of cancer, though their role is varied and complex. Cytokines have been mainly developed as a diagnostic or prognostic biomarker using a single measurement from a cohort of patients. Dynamic changes in cytokines may inform us about the prognostic impact of therapy under investigation.

Methods

We investigated retrospectively whether a panel of selected cytokines could be used as a potential biomarker to assess treatment response and predict the prognosis of pancreatic ductal adenocarcinoma (PDAC) patients (n=19) treated with combination of Gemcitabine, nab-Paclitaxel and all-trans-retinoic acid (ATRA), in the Phase I trial (STARPAC, NCT03307148). We measured cytokine levels in the plasma sampl

SUBMITTER: Hughes CS 

PROVIDER: S-EPMC12827075 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature