Exploring cell death mechanisms in liver transplantation: implications for graft survival.

ABSTRACT: Liver transplantation (LT) has become a life-saving therapy for patients with end-stage liver disease and malignancies. However, graft survival remains a significant challenge because of LT-related stresses. Grafts are subject to several stresses, including cold preservation after procurement and during transportation, as well as warm ischemia until vascular reconstitution, which can trigger hepatic cell death. This review examines the various cell death mechanisms that influence liver graft outcomes, including apoptosis, necrosis, autophagy, and non-apoptotic inflammatory cell death. We discuss how these mechanisms are driven by ischemia-reperfusion injury, which contributes to graft dysfunction. Apoptosis leads to the selective elimination of damaged hepatic cells, while necrosis, result

SUBMITTER: Hirao H 

PROVIDER: S-EPMC12827095 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature